[1P-0944] 2,6-bis-(4-hydroxy-3-methoxy-benzylidene)-cyclohexanone (BHMBC), a synthetic cyclohexanone curcumin analog inhibits the progression of castration-resistance prostate cancer in vitro and in vivo.

〇Sariya Mapoung^1,2,5、Shugo Suzuki⁵、Satoshi Fuji⁵、Pornsiri Pitchakarn¹、Supachai Yodkeeree^1,2、Sonthaya Umsumarng^1,2、Wanisa Punfa^1,2、Natee Sakorn^3,4、Chitchamai Ovatlarnporn^3,4、Satoru Takahashi⁵、Pornngarm Limtrakul^1,2 (1.Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand 、2.Center for Research and Development of Natural Products for Health, Chiang Mai University, Chiang Mai, Thailand、3.Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand 、4.Drug Delivery System Excellence Center, Prince of Songkla University, Hat-Yai, Songkhla, Thailand、5.Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Science, Nagoya City University, Nagoya, Japan)

Curcumin analog、Cyclohexanone、Prostate cancer、Cancer progression、Pharmacokinetic study