[1P-0963] Inhibition of IMPDH as An Effective Treatment for MLL-fusion Leukemia

〇Xiaoxiao Liu¹, Susumu Goyama¹, Shiori Shikata¹, Yasutaka Hayashi¹, Hiroyuki Iwamura³, Motoki Saitou², Yuki Sugiura⁴, Hitoshi Takizawa⁵, Satoshi Kofuji⁶, Kazutaka Sumita⁶, Atsuo Sasaki⁶, Janet Schibler⁷, James C. Mulloy⁷, Toshio Kitamura¹ (1.Division of Cellular Therapy, IMSUT, Univ. of Tokyo, Tokyo, Japan., 2.FUJIFILM Corporation: Pharmaceutical & Healthcare Research Laboratories, 3.FUJIFILM Corporation:Pharmaceutical Products Division, 4.Keio University, Sch. of Medicine, Dept. of Biochemistry, 5.IRCMS, Kumamoto University, 6.Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Univ. of Cincinnati College of Medicine, 7.UC Cancer Institute,Dept. of Internal Medicine, Division of Hematology Oncology, UC Neuroscience Institute: Dept. of Neurosurgery, Brain Tumor Center, Univ.of Cincinnati, College of Medicine)

MLL-fusion leukemia、IMPDH inhibitor、P21、P53