5:45 PM - 6:05 PM

[1PW08-6] Understanding the molecular mechanism of synergistic effect of EGFR-TKI and transcriptional inhibitor by Genome-wide CRISPR screen.

LOD 【J】

〇Hideki Terai^1,7, Danielle Potter¹, Shunsuke Kitajima¹, Yusuke Matsui⁵, Tae-jung Kim¹, Maria Rusan¹, Tran Thai¹, Federica Piccioni⁴, Katherine A Donovan^2,3, Nicholas Kwiatkowski³, Kunihiko Hinohara¹, Guo Wei⁶, Nathanael S Gray^2,3, Eric S Fischer^2,3, Teppei Shimamura⁵, Anthony Letai¹, Peter S Hammerman¹, David A Barbie¹ (1.Department of Medical Oncology, Dana Farber Cancer Institute, 2.Department of Cancer Biology, Dana Farber Cancer Institute, 3.Department of Biological Chemistry and Molecular Pharmacology, 4.Genetic Perturbation Platform, Broad Institute of Harvard and MIT, 5.Department of Systems Biology Nagoya University, Graduate School of Medicine, 6.Cancer Program, Broad Institute or MIT and Harvard, 7.Pulmonary medicine, Kitasato Institute Hospital)

ufmylation、CRISPR screening、EGFR-TKI、CDK7、CDK12