[3P-0511] Piperlongumine induces cell death through ROS-JNK-ERK activation and its proteasome inhibitory activity in cholangiocarcinoma cells

〇Chutima Talabnin¹, Sunisa Thongsom¹, Wipa Suginta¹, Kyung Jin Lee², Han Choe³ (1.Biochemistry-Electrochemistry Research Unit and School of Chemistry, Institute of Science, Suranaree University of Technology, Thailand, 2.Department of Convergence Medicine, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Korea , 3.Department of Physiology, Asan-Minnesota Institute for Innovating Transplantation, Bio-Medical Institute of Technology, University of Ulsan College of Medicine, Asan Medical Center, Korea )

Piperlongumine、Cholangiocarcinoma、ROS accumulation、anti-tumor activity