12:35 PM - 12:45 PM

[4LT16-06（3P-0593）] Replication stress induces R-loop-dependent accumulation of FANCD2 at the large fragile genes

〇Yusuke Okamoto^1,2, Wataru Iwasaki³, Kazue Takahashi³, Kazuto Kugou⁴, Arisa Oda⁴, Hidehiko Kawai⁵, Koichi Sato⁶, Wataru Kobayashi⁶, Ryo Sakasai⁷, Akifumi Takaori², Takashi Yamamoto⁸, Masato M. Kanemaki^9,10, Masato Taoka¹¹, Toshiaki Isobe¹¹, Hitoshi Kurumizaka⁶, Hideki Innan³, Kunihiro Ohta⁴, Masamichi Ishiai¹, Minoru Takata¹ (1.Dept. of Late Effect, RBC, Kyoto Univ., 2.Dept. of Hematol. and Oncol., Grad. Sch. of Med., Kyoto Univ., 3.SOKENDAI (The Grad. Univ. for Advanced Studies), 4.Dept. of Life Sci., Grad. Sch. of Arts and Sci., The Univ. of Tokyo, 5.Dept. of Mol. Radiobiology, Res. Inst. for Rad. Biol. and Med., Hiroshima Univ., 6.Lab. of Struct. Biol., Grad. Sch. of Adv. Sci. and Engin., Waseda Univ., 7.Dept. of Biochem. I, Sch. of Med., Kanazawa Med. Univ., 8.Dept. of Math. and Life Sci., Grad. Sch. of Sci., Hiroshima Univ., 9.Div. of Mol. Cell Engin., Nat. Inst. of Genet., ROIS, 10.Dept. of Genet., SOKENDAI, 11.Dept. of Chem., Grad. Sch. of Sci. and Engin., Tokyo Metro. Univ.)

replication stress、R-loop、FANCD2、common fragile cite