[2P-1435] Development of inhibitor of telomere binding protein using DSE-FRET assay

〇Yoshitomo Shiroma¹, Go Fujita¹, Masaki Kinehara¹, Mariko Ikuo¹, Akira Shimamoto¹, HIdetoshi Tahara¹ (1.Dept. Cell. Mol. Biol., Grad. Sch. Biomed. Sci., Hiroshima Univ.)

ConBio2017

[2P-1436] Target pathway analysis of an antitumor compound JBIR-140 by a global screen for drug sensitivity genes

〇Shohei Takase^1,2, Yasumitsu Kondoh^3,4, Takehiro Suzuki⁵, Naoshi Dohmae⁵, Kazuo Shin-ya⁶, Hiroyuki Osada^3,4, Tetsuo Kushiro², Ken Matsumoto^1,7,8, Minoru Yoshida^1,7,8 (1.Chemical Genomics Res. Gr., RIKEN CSRS, 2.Grad. Sch. of Agri., Meiji Univ., 3.Chemical Biology Res. Gr., RIKEN CSRS, 4.Chemical Bank Unit Drug Discov., RIKEN CSRS, 5.Biomol. Charact. Unit., RIKEN CSRS, 6.Biotech. Res. Inst. Drug Discov., AIST, 7.Chemical Genetics Lab., RIKEN, 8.Seed Cpds Explor. Unit Drug Discov., RIKEN CSRS)

ConBio2017

[2P-1437] Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

〇Yukiya Sako¹, Kensuke Ninomiya¹, Yukiko Okuno², Masayasu Toyomoto¹, Atsushi Nishida³, Yuka Koike¹, Kenji Ohe¹, Isao Kii¹, Suguru Yoshida⁵, Naohiro Hashimoto⁴, Takamitsu Hosoya⁵, Masafumi Matsuo³, Masatoshi Hagiwara¹ (1.Dept. of Anat. and Deve. Bio., Grad. Sch. Med., Kyoto Univ., 2.Med. Res. Sprt. Cent., Kyoto Univ. Grad. Schl. Med., 3.Dept. of Med. Reha., Koubegakuin Univ., 4.Dept. of Reg. Med., Nat. Cent. Geriatr. and Gerontol., 5.IBB, Tokyo Medi. & Dent. Univ.)

ConBio2017

[2P-1438] Exploring biologically active natural compounds against human colon cancer cell proliferation derived from soil microbial consortia

〇Shunsuke Ichikawa¹, Ayami Nishida², Fumiyoshi Okazaki^3,4, Hiroko Nakayama⁵, Norihiro Nishimura⁵, Yasuhito Shimada^4,6 (1.Dept. of Sci., Fac. of Edu., Mie Univ., 2.Dept. of Adv. Prac. for Prof. Teach. and Sch. Lead., Grad. Sch. of Edu., Mie Univ., 3.Dept. of life Sci., Grad. Sch. of Bio., Mie Univ., 4.Dept. Bioinfo., Ad. Sci. Res., Mie Univ., 5.Grad. Sch, Regional Innov., Mie Univ., 6.Dept. of Pharmacol., Grad. Sch. Med., Mie Univ.)

ConBio2017

[2P-1439] Development of pathway-oriented screening system and discovering glycolytic enzyme inhibitors

〇Kouichi Yanagi¹, Toru Komatsu¹, Hirotatsu Kojima³, Takayoshi Okabe³, Tetsuo Nagano³, Yasuteru Urano^1,2,4 (1.Grad. Sch. of Pharm. Sci., Univ. of Tokyo, 2.Grad. Sch. of Med., Univ. of Tokyo, 3.Drug Discovery Initiative, 4.AMED CREST)

ConBio2017

[2P-1440] Acquisition of the peptides that inhibit or activate receptor tyrosine kinase

〇Mai Matsushita¹, Rika Himeno², Aki Akahoshi², Shun Amemiya¹, Takashi Sato¹, Hiroshi Morioka¹, Yoshihiro Kobashigawa¹ (1.Grad. Sch. Pharm. Sci. Kumamoto Univ., 2.Sch.of Pharm.Kumamoto Univ.)

ConBio2017

[2P-1441] Structural Basis for Polyspecific Recognition of Non-natural Amino Acids by Pyrrolysyl-tRNA Synthetase

〇Tatsuo Yanagisawa¹, Mitsuo Kuratani¹, Eiko Seki¹, Nobumasa Hino³, Kensaku Sakamoto², Shigeyuki Yokoyama¹ (1.Struct. Biol. Lab., RIKEN, 2.CLST, RIKEN, 3.Grad.Sch.Pharm.Sci., Osaka Univ. )

ConBio2017

[2P-1442] The mechanism of action of dinapinones on inhibition of neutral lipid accumulation in mammalian cells

〇Keisuke Kobayashi¹, Taichi Ohshiro¹, Nobuhiro Koyama¹, Satoshi Ohte¹, Hiroshi Tomoda ¹ (1.Sch. of Pharm., Kitasato Univ.)

ConBio2017

[2P-1443] Novel isoquinoline ligands inhibiting MBNL1-CUG_exp interaction in Myotonic Dystrophy type1

〇Jun Matsumoto¹, Jinxing Li¹, Asako Murata¹, Chikara Dohno¹, Kazuhiko Nakatani¹ (1.The ISIR, Osaka Univ.)

ConBio2017

[2P-1444] Measuring E2 activities by artificial RING fingers in cancer cells

〇Mayumi Sunagawa¹, Arisa Nakatani¹, Kazuki Saito¹, Kazuhide Miyamoto¹ (1.Dept. of Pharm. Sci. Himeji Dokkyo Univ.)

ConBio2017