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[2P-133] (2T10a-11)Crystal structure of trypanosome alternative oxidase (TAO) in complex with a new inhibitor, ferulenol.

Ueda Satoshi1, Shiba Tomoo1, Takahashi Gen1, Inaoka Daniel Ken2, Kido Yasutoshi2, Sakamoto Kimitoshi2, Tsuge Tiaki2, Balogun Oluwadare Emmanuel2, Nara Takeshi3, Aoki Takashi3, Honma Teruki4, Tanaka Akiko4, Inoue Masayuki5, Matsuoka Shigeru5, Moore L. Anthony6, Saimoto Hiroyuki7, Harada Shigeharu1, Kita Kiyoshi2 (1.Dept. Appl. Biol., Grad. Sch. Sci. and Tech., Kyoto Institute of Technology, 2.Dept. Biomed. Chem., Grad. Sch. Med., The University of Tokyo, 3.Dept. Mol. Cell Parasitol., Sch. Med. Juntendo Univ., 4.Sys. Struc. Biol. Center, RIKEN, 5.Grad. Sch. Pharm. Sci., Univ. of Tokyo, 6.Biochem. Biomed. Sci., Sch. of Life Sci., Univ. of Sussex, 7.Dept. Materials Sci., Grad. Sch. Eng., Tottori Univ.)

Alternative Oxidase, Trypanosoma, Crystal structure, Ferulenol, drug design

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