14:00 〜 15:00

[2P-299] Hypoxia-inducible factorsによる低酸素環境下におけるCystathionine β-synthaseの遺伝子発現制御機構の解明

^○高野 直治^1,2,3,4, Peng Ying-Jie⁵, Kumar Ganesh K.⁵, Luo Weibo^2,6, Hu Hongxia^2,3, Shimoda Larissa A.^7,8, 末松 誠^1,4, Prabhakar Nanduri R.⁵, Semenza Gregg L.^{2,3,6,7,9,10,11} (1.JST ERATO 末松ガスバイオロジープロジェクト, 2.Inst. for Cell Engineering, Johns Hopkins Univ. School of Med., 3.McKusick-Nathans Inst. of Genetic Med., Johns Hopkins Univ. School of Med., 4.慶應大・医・医化学, 5.Inst. for Integrative Physiology and Center for Systems Biology of O2 Sensing, Univ. of Chicago, 6.Dept. of Biological Chemistry, Johns Hopkins Univ. School of Med., 7.Dept. of Med., Johns Hopkins Univ. School of Med., 8.Div. of Pulmonary and Critical Care Med., Johns Hopkins Univ. School of Med., 9.Dept. of Pediatrics, Johns Hopkins Univ. School of Med., 10.Dept. of Oncology, Johns Hopkins Univ. School of Med., 11.Dept. of Radiation Oncology, Johns Hopkins Univ. School of Med.)

低酸素, 硫化水素, HIF, CBS