10:20 AM - 10:28 AM

[2T10a-11] (2P-133)Crystal structure of trypanosome alternative oxidase (TAO) in complex with a new inhibitor, ferulenol.

^○Ueda Satoshi¹, Shiba Tomoo¹, Takahashi Gen¹, Inaoka Daniel Ken², Kido Yasutoshi², Sakamoto Kimitoshi², Tsuge Tiaki², Balogun Oluwadare Emmanuel², Nara Takeshi³, Aoki Takashi³, Honma Teruki⁴, Tanaka Akiko⁴, Inoue Masayuki⁵, Matsuoka Shigeru⁵, Moore L. Anthony⁶, Saimoto Hiroyuki⁷, Harada Shigeharu¹, Kita Kiyoshi² (1.Dept. Appl. Biol., Grad. Sch. Sci. and Tech., Kyoto Institute of Technology, 2.Dept. Biomed. Chem., Grad. Sch. Med., The University of Tokyo, 3.Dept. Mol. Cell Parasitol., Sch. Med. Juntendo Univ., 4.Sys. Struc. Biol. Center, RIKEN, 5.Grad. Sch. Pharm. Sci., Univ. of Tokyo, 6.Biochem. Biomed. Sci., Sch. of Life Sci., Univ. of Sussex, 7.Dept. Materials Sci., Grad. Sch. Eng., Tottori Univ.)

Alternative Oxidase, Trypanosoma, Crystal structure, Ferulenol, drug design