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[4P-409] Overexpression of LARGE suppresses muscle regeneration via down-regulation of IGF-1 and aggravates muscular dystrophy in mice

Saito Fumiaki1, Kanagawa Motoi2, Ikeda Miki1, Hagiwara Hiroki1,3, Masaki Toshihiro1,3, Ohkuma Hidehiko1, Katanosaka Yuki4, Shimizu Teruo5, Sonoo Masahiro1, Toda Tatsushi2, Matsumura Kiichiro1 (1.Dept. of Neurol., Sch. of Med., Teikyo Univ,, 2.Dept. of Neurol./Mol. Brain Sci., Univ. of Kobe, 3.Dept. of Med. Sci., Teikyo Univ. of Sci., 4.Dept. of Cardiovascul. Physiol., Okayama Univ., 5.Dept. of Sport and Med. Sci., Teikyo Univ.)

筋ジストロフィー, dystroglycan, LARGE, 筋再生, insulin-like growth factor-1

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