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[4P-411] Establishment of progressive familial intrahepatic cholestasis type 2 model using patient specific iPS cell-derived hepatocyte-like cells

Imagawa Kazuo1, Takayama Kazuo1,2,4, Isoyama Shigemi3, Noguchi Emiko5, Shinkai Masato6, Tachibana Masashi1, Sakurai Fuminori1, Kawabata Kenji7, Sumazaki Ryo3, Mizuguchi Hiroyuki1,2,4,8 (1.Lab. of Biochem. and Mol. Biol.,Grad. Sch. of Pharm. Sci., Osaka Univ., 2.Lab. of Hepat. Reg., NIBIO., 3.Dept. of Child Health, Fac. of Med., Univ. of Tsukuba, 4.iPS Cell-based Res. Proj. on Hepatic Toxi. and Metab., Grad. Sch. of Pharm. Sci., Osaka Univ., 5.Dept. of Genetics, Fac. of Med., Univ. of Tsukuba, 6.Div. of Surg., Kanagawa Children's Med. Center, 7.Lab. of Stem Cell Reg., NIBIO., 8.MEI Center, Osaka Univ.)

iPS細胞, BSEP, PFIC2型

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