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[4P-452] Inhibitory anti-human TLR4 monoclonal antibody induces an inactive TLR4 dimer for signaling

Yamagata Yuki1, Tsukamoto Hiroki2, Ukai Ippo1, Suzuki Naoto2, Tomioka Yoshihisa2 (1.Lab. of Oncol., Pharm. Pract & Sci., Fac. of Pharm. Sci, Tohoku Univ., 2.Lab. of Oncol., Pharm. Pract & Sci., Grad. Sch. of Pharm. Sci, Tohoku Univ.)

Toll-like receptor 4, lipopolysaccharide, モノクローナル抗体

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