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[4T14a-10] (4P-290)B cell-fate determination by mitochondrial ROS via inhibition of heme synthesis

Jang Kyoung-Jin1, Mano Hiroto1, Aoki Koji2, Hayashi Tatsunari1, Muto Akihiko3, Nambu Yukiko1, Hara Eri1, Takahashi Katsu4, Itoh Katsuhiko5, Taketani Shigeru6, Igarashi Kazuhiko3, Shimizu Akira1, Sugai Manabu1 (1.Dept. of Exp. Therapeu., Inst. of Adv. of Clin. and Transl. Sci., Kyoto Univ. Hosp., 2.Div. of Pharmacol., Sch. of Med., University of Fukui, 3.Dept. of Biochem., Sch. of Med., Tohoku University, 4.Dept. of Oral & Maxillofacial Surgery, Kyoto Unv. Hosp., 5.Dept. of Clin. Mol. Biol., Kyoto Univ. Hosp., 6.Dept. of Biotech., Kyoto Inst. Tech.)

Class Switch Recombination, Plasma Cell Differentiation, Bach2, Blimp1, Heme

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