1:30 PM - 2:45 PM

[1P-047(1T08-03)] Conjugation of synthetic N-glycans to recombinant human lysosomal enzymes derived from transgenic silkworms and therapeutic application for lysosomal diseases

^○So-ichiro Nishioka^1,9, Isao Kobayashi^3,9, Akira Harazono^4,10, Yuhki Kubo⁵, Yuji Matsuzaki⁶, Nobuo Maita⁷, Tomo Hidaka², Daisuke Tsuji^1,9, Hideki Sezutsu^3,9,10, Hiroaki Machii^3,9, Akiko Ishii^4,10, Nana Kawasaki^8,10, Kohji Itoh^1,9,10 (1.Grad. Sch. of Pharmaceut Sci., Tokushima Univ., 2.Facult. of Pharmaceut Sci., Tokushima Univ., 3.NARO, 4.NIHS, 5.Masuda Chem. Inds. Co., Ltd., 6.Tokyo Chem. Inds. Co., Ltd., 7.Inst. for Enz. Res., Tokushima Univ., 8.Grad. Sch. of Med. Life Sci., The Univ. of Yokohama City, 9.Agrihealth PT, 10.AMED)

リソソーム酵素, エンドグリコシダーゼ, TGカイコ, 人工糖鎖修飾, 酵素補充療法