2:45 PM - 3:45 PM

[1P-086] Serendipitous discovery of trypanocidal compounds with dual-inhibition for African trypanosomes glycerol kinase and alternative oxidase

^○Emmnuel O. Balogun¹, Daniel K. Inaoka¹, Tomoo Shiba², Chiaki Tsuge¹, Benjamin May³, Tomohiro Sato⁴, Yasutoshi Kido¹, Takeshi Nara⁵, Takashi Aoki⁵, Teruki Honma⁴, Akiko Tanaka⁴, Masayuki Inoue⁶, Shigeru Matsuoka⁶, Paul A.M. Michels⁷, Anthony L Moore³, Shigeharu Harada², Kiyoshi Kita¹ (1.Grad. Sch. of Med., The Univ. of Tokyo, 2.Grad. Sch. of Sci. and Tech., Kyoto Inst. of Tech, 3.Biochem. and Biomed., Sch. of Life Sci., Univ. of Sussex, UK, 4.System and Struct. Biol. Center, RIKEN, 5.Juntendo Univ. Sch. of Med., 6.Grad. Sch. of Pharm. Sci., The Univ. of Tokyo, 7.Sch. of Biol. Sci., Univ. of Edinburgh, Scotland, UK)

Energy metabolism, African trypanosomiasis, rational drug design, inhibitor, screening