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[1P-281] Anomalous islet structure in diabetic cysteine414-alanine-mCRY1 transgenic mice

Satoshi Okano1, Akira Yasui2, Shin-ichiro Kanno2, Kiyoshi Hayasaka3,4, Igarashi Masahiko5, Osamu Nakajima1 (1.Inst. for Promotion of Med. Sci. Res., Fac. of Med., Yamagata Univ., 2.IDAC, Tohoku Univ., 3.Dept. of Pediat., Fac. of Med., Yamagata Univ, 4.Miyukikai Hosp., 5.Yamagata City Hosp. Saiseikan)

β-cell dysfunction, dedifferentiation, SASP, diabetes, circadian clock

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