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[2P-114] Crystal structure of the trypanosome cyanide-insensitive alternative oxidase (TAO) in complex with a new coumarin derivative.

Machi Saito1, Tomoo Shiba1, Satoshi Ueda1, Daniel Ken Inaoka2, Yasutoshi Kido3, Emmanuel Oluwadare Balogun3, L. Moore Anthony4, Hiroyuki Saimoto5, Kiyoshi Kita6, Shigeharu Harada1 (1.Dept. Appl. Biol., Grad. Sch. Sci. and Tech., Kyoto Institute of Technology, 2.Cent. for Int. Collabo. Res., Nagasaki Univ., 3.Dept. Biomed. Chem., Grad. Sch. Med., Univ. of Tokyo, 4.Biochem. Biomed. Sci., Sch. of Life Sci., Univ. of Sussex, 5.Dept. Materials Sci., Grad. Sch. Eng., Tottori Univ., 6.Sch. of Tropical Med. Global Health, Nagasaki Univ.)

Alternative Oxidase, Trypanosoma, Crystal structure, Glycerol kinase, drug design

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