5:40 PM - 6:05 PM

[2S09-4] Targeting hypoxic response for the treatment of diseases: Renal anemia and lethal lactic acidosis

Tomoko Oyaizu-Toramaru^1,2, Tomohiro Suhara^1,2, Noriyo Hayakawa^1,3, Takashi Nakamura¹, Shizuka Minamishima², Kyoji Yamaguchi⁴, Takako Hishiki^1,3, Hiroshi Morisaki², Makoto Suematsu¹, ^○Yoji Andrew Minamishima^1,2,5 (1.Dep. of Biochem., Keio Univ. School of Medicine, 2.Dep. of Anaesthesiology, Keio Univ. School of Medicine, 3.Translational Research Center, Keio Univ. School of Medicine, 4.Rare disease & LCM laboratories, Daichi Sankyo Co. Ltd., 5.Div. of Cell Biol., Dep. of Mol. and Cell. Biol., Med. Inst. of Bioreg., Kyushu Univ.)

hypoxia, 低酸素, HIF, PHD阻害剤, PHD inhibitor, lactic acidosis, metformin, メトホルミン, 乳酸アシドーシス