[1P-011] CDK4/6 inhibitor abemaciclib induce the cell death with formation of vacuole derived from lysosome

^○Hino Hirotsugu¹, Iriyama Noriyoshi², Kokuba Hiroko³, Kazama Hiromi¹, Moriya Shota¹, Takano Naoharu¹, Hiramoto Masaki¹, Miyazawa Keisuke¹ (1.Dep. of Biochem, Tokyo Med. Univ., 2.Div. of Hematol. And Rheumatol., Dep. of Med, Nihon Univ., 3.Joint Res. Center for Basic Med. Sci., Tokyo Med. Univ.)

キーテクノロジー：ライブセルイメージング

CDK4/6阻害薬、abemaciclib、リソソーム、細胞死、空胞形成