[1P-115] Identification of ubiquinone binding site of Ndi1, a yeast Type II NADH dehydrogenase, by revealing co-crystal structure with novel competitive and mixed-type inhibitors

^○Yamashita Tetsuo¹, Inaoka Daniel K.^2,3, Shiba Tomoo⁴, Oohashi Takumi², Iwata So^5,6,7,8, Yagi Takao⁹, Kosaka Hiroaki¹, Miyoshi Hideto¹⁰, Harada Shigeharu⁴, Kita Kiyoshi^2,3, Hirano Katsuya¹ (1.Dept. of Cardiovascular Physiol., Fac. of Med., Kagawa Univ., 2.Dept. of Biomed. Chem., Grad. Sch. of Med., The Univ. of Tokyo, 3.Sch. of Trop. Med. and Glob. Health, and Inst. of Trop. Med., Nagasaki Univ., 4.Dept. of Appl. Biol., Grad. Sch. of Sci. and Tech., Kyoto Inst. of Tech., 5.Div. of Mol. Biosci., Memb. Prot. Crystallogr. Group, Imperial Coll., 6.Memb. Prot. Lab., Diamond Light Sour., 7.Dept. of Cell Biol., Grad. Sch. of Med., Kyoto Univ., 8.Sys. and Struc. Biol. Center, RIKEN, 9.Dept. of Mol. and Experiment. Med., The Scripps Res. Inst., 10.Div. of Appl. Life Sci., Grad. Sch. of Agri., Kyoto Univ.)

キーテクノロジー：1分子構造解析

NADH脱水素酵素、反応機構、基質結合部位、ユビキノン、X線結晶構造解析