Fc fusion of single-chain TNFR1 selective antagonistic TNF-alpha mutant protein enhances in vivo molecular stability

Inoue Masaki

[1P-355] Fc fusion of single-chain TNFR1 selective antagonistic TNF-alpha mutant protein enhances in vivo molecular stability

^○Inoue Masaki^1,2, Osaki Natsuki¹, Kunishige Masahiro¹, Miki Midori¹, Onodera Akira¹, Kawai Yuichi¹, Kamada Haruhiko^2,3, Tsutsumi Yasuo³, Tsunoda Shin-ichi^1,2 (1.Fac. Pharm. Sci., Kobe Gakuin Univ., 2.NIBIOHN, 3.Grad. Sch. Pharm. Sci., Osaka Univ.)

キーテクノロジー：サイトカイン変異体の一本鎖構造安定化技術

TNF阻害薬、アンタゴニスト、Fc融合タンパク質、長時間作用型

m-inoue@pharm.kobegakuin.ac.jp

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The 91th Annual Meeting of JBS

[1P-355] Fc fusion of single-chain TNFR1 selective antagonistic TNF-alpha mutant protein enhances in vivo molecular stability

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