13:09 〜 13:21

[1T12a-03(1P-127)] Biochemical and structural characterizations of a non-canonical isocitrate dehydrogenase with activity towards NADP and NAD localized in Trypanosoma brucei

^○Xinying Wang^1,2, Daniel Ken Inaoka^1,2,3, Emmanuel O Balogun¹, Nicole Ziebart⁴, Stefan Allmann⁵, Michael Boshart⁴, Frederic Bringaud⁵, Tomoo Shiba⁶, Shigeharu Harada⁶, Kiyoshi Kita^1,2,3 (1.Dept. of Biomedical Chemistry, Graduate School of Medicine, Univ. Tokyo, 2.School of Tropical Medicine and Global Health, Univ. Nagasaki, 3.Dept. of Host-Defense Biochemistry, Institute of Tropical Medicine, Univ. Nagasaki, 4.Biocenter, Genetics, Ludwig Maximilians Univ. Munich, 5.Magnetic Resonance Center of Biological Systems, Univ. Bordeaux, 6.Dept. of Applied Biology, Kyoto Institute of Technology)

キーテクノロジー：enzyme characterization and crystallography

isocitrate dehydrogenase 、coenzyme specificity、trypanosome、metabolism、glycosome