The Japanese Biochemical Society

[2P-190(2T12e-08)] Phosphorylation of RNF43 is an essential switch to suppress Wnt signalling and regulates embryonic development, stem cell maintenance and tumorigenesis.

Tsukiyama Tadasuke1, Terai Sayuri1, Takahashi Hidehisa2, Ishitani Tohru3, Koo Bon-Kyoung4, Hatakeyama Shigetsugu1 (1.Hokkaido University Faculty of Medicine and Graduate School of Medicine, Department of Biochemistry, 2.Yokohama City University Graduate School of Medical Science, Department of Molecular Biology, 3.Gunma University, Institute for Molecular and Cellular Regulation, Laboratory of Integrated Signaling Systems, 4.Institute of Molecular Biotechnology, Austria)

キーテクノロジー:organoid assay

Wnt、RNF43、tumorigenesis、stem cell、homeositasis

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