[2P-312] Excision of expanded CTG repeat of myotonic dystrophy by CRISPR/Cas9 -Comparison between Cas9 nuclease and Cas9 nickase-

^○Saito Fumiaki¹, Ikeda Miki¹, Hagiwara Hiroki², Masaki Toshihiro², Shimizu Teruo³, Matsumura Kiichiro¹, Sonoo Masahiro¹ (1.Department of Neurology, Teikyo University, School of Medicine,, 2.Department of Medical Science, Teikyo University of Science, 3.Faculty of Medical Technology, Teikyo University)

キーテクノロジー：genome editing

CRISPR、Cas9、paired nicking、myotonic dystrophy