The increment of membrane cholesterol aggravates endocytic disturbance, resulting in enhanced A&beta; accumulation: mechanism underlying acceleration of A&beta; pathology by type 2 diabetes mellitus

Kimura Nobuyuki

[2P-332(2T13m-04)] The increment of membrane cholesterol aggravates endocytic disturbance, resulting in enhanced Aβ accumulation: mechanism underlying acceleration of Aβ pathology by type 2 diabetes mellitus

^○Kimura Nobuyuki¹, Takeuchi Shingo¹, Ueda Naoya¹, Suzuki Keiko¹, Shimozawa Nobuhiro², Yasutomi Yasuhiro² (1.Section of Cell Biol & Pathol., Dept. Alzheimer's Dis. Res., NCGG, 2.Tsukuba Primare Research Center, NIBIOHN)

キーテクノロジー：ウエスタンブロット

アルツハイマー病、２型糖尿病、コレステロール、エンドサイトーシス、アミロイドβ

kimura@ncgg.go.jp

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The 91th Annual Meeting of JBS

[2P-332(2T13m-04)] The increment of membrane cholesterol aggravates endocytic disturbance, resulting in enhanced Aβ accumulation: mechanism underlying acceleration of Aβ pathology by type 2 diabetes mellitus

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