[1P-015] Heparan sulfate S-domains that accumulate in kidney transthyretin deposits accelerate fibril formation and promote cytotoxicity

^○Kazuchika Nishitsuji¹, Kenji Uchimura², Taro Yamashita³, Kaori Kuwabara⁴, Hirokazu Kameyama⁴, Mineyuki Mizuguchi⁵, Keiichiro Okuhira⁴, Yoshito Ihara¹, Takashi Ohgita⁶, Hiroyuki Saito⁶, Yukio Ando⁷ (1.Department of Biochemistry, Wakayama Medical University, 2.Unite de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS, Universite de Lille 1, 3.Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 4.Department of Molecular Physical Pharmaceutics, Institute of Biomedical Sciences, Tokushima University Graduate School, 5.Faculty of Pharmaceutical Sciences, University of Toyama, 6.Department of Biophysical Chemistry, Kyoto Pharmaceutical University, 7.Department of Neurology, Graduate School of Medical Sciences, Kumamoto University)

キーテクノロジー：細胞外スルファターゼ

ヘパラン硫酸、トランスサイレチン、アミロイドーシス、アミロイド、Sulf