Deletion of class II ARFs in mice causes tremor by inhibiting Nav1.6 localization to cerebellar Purkinje cell axon initial segments.

Tetsushi Sadakata

[1P-148] Deletion of class II ARFs in mice causes tremor by inhibiting Nav1.6 localization to cerebellar Purkinje cell axon initial segments.

^○Tetsushi Sadakata¹, Nobutake Hosoi², Koji Shibasaki³, Ayumu Konno², Hirokazu Hirai², Yasuki Ishizaki³, Teiichi Furuichi⁴ (1.Education and Research Support Center, Gunma University Graduate School of Medicine, 2.Department of Neurophysiology and Neural Repair, Gunma University Graduate School of Medicine, 3.Department of Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, 4.Department of Applied Biological Science, Tokyo University of Science)

キーテクノロジー：遺伝子改変マウス

ARF、Nav1.6、AIS、trafficking

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[1P-148] Deletion of class II ARFs in mice causes tremor by inhibiting Nav1.6 localization to cerebellar Purkinje cell axon initial segments.

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