[1P-302] New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis

^○Shinichi Inoue¹, Shingo Takahara^1,2, Sachiko Miyagawa-Tomita^3,4, Katsuhisa Matsuura⁵, Yasumi Nakashima⁶, Tetsuya Niihori¹, Yoichi Matsubara^1,7, Yoshikatsu Saiki², Yoko Aoki¹ (1.Department of Medical Genetics, Tohoku University Graduate School of Medicine, 2.Division of Cardiovascular Surgery, Graduate School of Medicine, Tohoku University, 3.Department of Animal Nursing Science, Yamazaki University of Animal Health Technology, 4.Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 5.Institute of Advanced Biomedical Engineering and Science, Tokyo Womens Medical University, 6.Department of Pediatrics, Seirei Hamamatsu General Hospital, 7.National Center for Child Health and Development)

キーテクノロジー：ノックインマウス

RIT1、ヌーナン症候群、筋線維芽細胞、心臓線維化、AKT