The Japanese Biochemical Society

[1P-359] Identification of a novel ligand-binding cavity realizing the inhibition of cell adhesion mediated by P-cadherin, a protein forming homophilic dimerization

Akinobu Senoo1, Satoru Nagatoishi2, Kouhei Yoshida3, Sho Ito4, Go Ueno4, Takumi Tashima1, Shota Kudo1, Kouhei Tsumoto1,2,3 (1.Dept. of Chem. Biotech., Sch. of Eng., Univ. of Tokyo, 2.Inst. of Med. Sci., Univ. of Tokyo, 3.Dept. of Bioeng., Sch. of Eng., Univ. of Tokyo, 4.RIKEN, SPring-8 Center)

キーテクノロジー:SPR, X線結晶構造解析

feagment based drug discovery、カドヘリン、蛋白質間相互作用、細胞接着、低分子阻害剤

a-senoo@protein.t.u-tokyo.ac.jp

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