[1P-359] Identification of a novel ligand-binding cavity realizing the inhibition of cell adhesion mediated by P-cadherin, a protein forming homophilic dimerization

^○Akinobu Senoo¹, Satoru Nagatoishi², Kouhei Yoshida³, Sho Ito⁴, Go Ueno⁴, Takumi Tashima¹, Shota Kudo¹, Kouhei Tsumoto^1,2,3 (1.Dept. of Chem. Biotech., Sch. of Eng., Univ. of Tokyo, 2.Inst. of Med. Sci., Univ. of Tokyo, 3.Dept. of Bioeng., Sch. of Eng., Univ. of Tokyo, 4.RIKEN, SPring-8 Center)

キーテクノロジー：SPR, X線結晶構造解析

feagment based drug discovery、カドヘリン、蛋白質間相互作用、細胞接着、低分子阻害剤