10:30 AM - 10:50 AM

[1S16m-05] Flanking residues of a Japanese cedar pollen allergen Cry j 1 peptide promotes homo assembly of HLA-DP5 and T-cell activation

Seisuke Kusano¹, Sho Ueda², Ohryoji Daisuke², Aya Toyoumi², Akiko Hashimoto-Tane³, Hiroshi Ike³, Wakana Kobayashi³, Hiroyuki Kishi⁴, Hiroshi Hamana⁴, Atsushi Muraguchi⁴, Hui Jin⁵, Hisashi Arase^5,6, Yoko Satta⁷, Hiroko Miyadera⁸, Chiemi Mishima-Tsumagari⁹, Ikeda Mariko⁹, Motoaki Wakiyama⁹, Takaho Terada¹, Mutsuko Kukimoto-Niino⁹, Mikako Shirouzu⁹, Reiko Kishikawa¹⁰, Yasunobu Yoshikai¹¹, Hisakata Yamada¹¹, Ken Yamamoto¹¹, Yasuharu Nishimura¹², Takashi Saito³, Takehiko Sasazuki², ^○Shigeyuki Yokoyama¹ (1.RIKEN Cluster for Science, Technology and Innovation Hub, 2.Institute for Advanced Study, Kyushu University, 3.RIKEN Center for Integrative Medical Sciences, 4.Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 5.WPI Immunology Frontier Research Center, Osaka University, 6.Research Institute for Microbial Diseases, Osaka University, 7.Center for Promotion of Integrated Sciences, The Graduate University for Advanced Studies, 8.Graduate School of Medicine, The University of Tokyo, 9.RIKEN Center for Biosystems Dynamics Research, 10.Department of Allergology, The National Hospital Organization Fukuoka Hospital, 11.Medical Institute of Bioregulation, Kyushu University, 12.Graduate School of Medical Sciences, Kumamoto University)

キーテクノロジー：X線結晶構造解析

MHC、抗原提示、スギ花粉症、T細胞活性化、多量体