[2P-132] Essential role of NOX3-mediated endosomal production of ROS in maintenance of sustained B cell receptor signaling and B cell proliferation

^○YangYang Feng¹, Miao Tang¹, Mitsuhiro Suzuki¹, Chinthika Gunasekara¹, Yuki Anbe¹, Yuichi Hiraoka², Jun Liu³, JiYang Wang³, Takeshi Tsubata¹ (1.Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, 2.Department of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, 3.Department of Immunology, School of Basic Medical Sciences, Fudan University)

キーテクノロジー：CRISPR

ROS、B cell receptor、NADPH oxidase