[2P-149] A novel mechanism of Rac1 activation as a therapeutic target for HER2-positive breast cancers

^○Masashi Maekawa^1,2, Akari Murakami^2,3, Katsuhisa Kawai⁴, Jun Nakayama⁵, Nobukazu Araki⁴, Kentaro Semba⁵, Tomohiko Taguchi⁶, Yoshiaki Kamei³, Yasutsugu Takada³, Shigeki Higashiyama^1,2 (1.Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, 2.Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, 3.Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, 4.Department of Histology and Cell Biology, School of Medicine, Kagawa University, 5.Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, 6.Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University)

キーテクノロジー：生細胞観察

Cullin-3 (CUL3)、Rac1、Membrane ruffle、HER2陽性乳癌、RhoB