The Japanese Biochemical Society

[2P-178] CDK4/6 inhibitor abemaciclib induces atypical cell death with formation of cytoplasmic vacuoles derived from lysosome

Hirotsugu Hino1,2, Noriyoshi Iriyama3, Hiroko Kokuba4, Hiromi Kazama1, Shota Moriya1, Naoharu Takano1, Masaki Hiramoto1, Keisuke Miyazawa1 (1.Dep. of Biochem, Tokyo Med. Univ., 2.Div. of Anat. Sci., Dep. of Funct. Morpho., Nihon Univ. Sch. of Med., 3.Div. of Hematol. And Rheumatol., Dep. of Med, Nihon Univ. Sch. of Med., 4.Joint Res. Center for Basic Med. Sci., Tokyo Med. Univ.)

キーテクノロジー:ライブセルイメージング

CDK4/6阻害薬、abemaciclib、リソソーム、細胞死、空胞形成

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