[2P-192] PARP1 inhibitors alleviate injury in ARH3-deficient mice and human cells

^○Kazumasa Aoyama¹, Masato Mashimo¹, Xiangning Bu¹, Jiro Kato¹, Hiroko Ishiwata-Endo¹, Linda A Stevens¹, Atsushi Kasamatsu¹, Lynne A Wolfe², Camilo Toro², David Adams^2,3, Thomas Markello², William A Gahl^2,3, Joel Moss¹ (1.Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), 2.NIH Undiagnosed Diseases Program, Common Fund, Office of the Director, National Institutes of Health (NIH), 3.Office of the Clinical Director, National Human Genome Research Institute, National Institutes of Health (NIH))

キーテクノロジー：DNA sequence

ARH3、Poly(ADP-ribosyl)ation、Parthanatos