[2P-324] Galectin 3 binding protein suppresses Aβ production via modulation of endogenous β-secretase activity

^○Tsuneyoshi Seki¹, Motoi Kanagawa¹, Kazuhiro Kobayashi¹, Hisatomo Kowa², Naoki Yahata^3,6, Kei Maruyama⁴, Nobuhisa Iwata⁵, Haruhisa Inoue^6,7,8, Tatsushi Toda^1,9 (1.Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, 2.Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, 3.Department of Anatomy I, Fujita Health University School of Medicine, 4.Department of Pharmacology, Faculty of Medicine, Saitama Medical University, 5.Department of Genome- based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, 6.Center for iPS Cell Research and Application (CiRA), 7.iPSC-based Drug Discovery and Development Team, RIKEN BioResource Research Center (BRC), 8.Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), 9.Department of Neurology, Graduate School of Medicine, The University of Tokyo)

キーテクノロジー：iPS細胞

Alzheimer’s disease、iPS細胞、GAL3BP、BACE1、microarray