The Japanese Biochemical Society

The 92nd Annual Meeting of JBS

The 92nd Annual Meeting of JBS

Sep 18, 2019 - Sep 20, 2019
Pacifico Yokohama

10:38 AM - 10:57 AM

[2S03m-06] The antipsychotic olanzapine targets proinsulin to endoplasmic reticulum-associated degradation by impairing proper disulfide bond formation

○Satoshi Ninagawa1, Tetsuya Okada1, Hajime Umezawa1, Tokiro Ishikawa1, Seiji Torii2, Robert Mackin3, Koshi Imami4, Yasushi Ishihama4, Takahiko Nagamine5, Kazutoshi Mori1 (1.Department of Biophysics, Graduate School of Science, Kyoto University, 2.Gunma University Center for Food Science and Wellness, 3.Department of Biomedical Sciences, Creighton University School of Medicine, 4.Department of Molecular and Cellular BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 5.Sunlight Brain Research Center)

キーテクノロジー：分子細胞生物学

糖尿病、インスリン、抗精神病薬、オランザピン、ジスルフィド結合

sninagawa@upr.biophys.kyoto-u.ac.jp

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