9:05 AM - 9:21 AM

[2S06m-01] Pyrimidine de novo biosynthesis in tumor microenvironment

^○Daniel K. Inaoka^1,2,3, Yukiko Miyazaki², Tomoo Shiba⁴, Hiroyuki Saimoto⁵, Eri Amalia³, Yasutoshi Kido^2,6, Chika Sakai³, Anthony L. Moore⁷, Shigeharu Harada⁴, Kiyoshi Kita^2,3,8 (1.Dept. of Mol. Infect. Dynamics., Inst. of Trop. Med. (NEKKEN), Nagasaki Univ., 2.Sch. of Trop. Med. and Global Health, Nagasaki Univ., 3.Dept. of Biomed. Chem., Grad. Sch. of Med., The Univ. of Tokyo., 4.Dept. of Appl. Biol., Grad. Sch. of Sci. and Tech., Kyoto Inst. of Tech., 5.Dept. of Mat. Sci., Grad. Sch. of Eng., Tottori Univ., 6.Dept. of Parasitol., Grad. Sch. of Med., Osaka City Univ., 7.Biochem. and Biomater. Sci., Sch. of Life Sci., Univ. of Sussex, 8.Dept. of Host-Defense Biochem., Inst. of Trop. Med. (NEKKEN), Nagasaki Univ.)

キーテクノロジー：膜蛋白質の結晶構造解析

ピリミジン生合成経路、ユビキノン結合部位阻害剤、生体エネルギー、がん微小環境、構造活性相関