[3P-205] Cdk5 increases MARK4 activity and augments pathological tau accumulation and toxicity through tau phosphorylation at Ser262

^○Saito Taro¹, Oba Toshiya¹, Shimizu Sawako¹, Akiko Asada¹, Koichi M. Iijima^2,3, Ando Kanae¹ (1.Dept Biol Sci, Tokyo Met Univ, Tokyo, Japan, 2.Dept Alzheimer's Dis Res, NCGG, Aichi, Japan, 3.Dept Exp Gerontology, Grad Sch Pharm Sci, Nagoya City Univ, Aichi, Japan)

キーテクノロジー：Drosophila model

tau、Cdk5、MARK