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[3T02m-04] Heme deficiency causes insulin resistance due to impaired glycogen synthesis induced by reducing AMP-activated kinase signals

Shinichi Saitoh1,2, Koen van Wijk1, Tomohiro Kimura1, Tsukasa Osaki3, Satoshi Okano1, Masayuki Yamamoto4, Hironobu Asao2, Kelly Vincent P.5, Kiwamu Takahashi6, Tohru Tanaka6, Motowo Nakajima6, Osamu Nakajima1 (1.Yamagata University School of Medicine, Research Center for Molecular Genetics, 2.Department of Immunology, Yamagata University School of Medicine, 3.Department of Public Health, Yamagata University School of Medicine, 4.Department of Medical Biochemistry, Tohoku University School of Medicine,, 5.Trinity Biomedical Sciences Institute, Trinity College Dublin, 6.SBI Pharmaceuticals Co.,Ltd.)

キーテクノロジー:ゲノム編集マウス

ヘム、グリコーゲン、インスリン抵抗性、5-アミノレブリン酸合成酵素、AMPK

nakajima@med.id.yamagata-u.ac.jp

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