[2P-082] Understanding the mechanism by which PDI family catalyze oxidative folding of precursor protein

^○Koki Masuda¹, Shingo Kanemura¹, Misaki Kinoshita², Hiroshi Yamaguchi¹, Yuji Hidaka³, Kenji Inaba⁴, Masaki Okumura² (1.Sch. of Sci. and Tech., Kwansei Gakuin Univ., 2.FRIS, Tohoku Univ., 3.Fac. of Sci. and Eng., Kindai Univ., 4.IMRAM, Tohoku Univ.)

The 92nd Annual Meeting of JBS

[2P-083] Mechanism of polyphosphate-induced aggregation of a globular protein

^○Kenji Sasahara, Keiichi Yamaguchi, Masatomo So, Yuji Goto (Osaka University IPR)

The 92nd Annual Meeting of JBS

[2P-084] mTORC2 signaling controls the lysosomal activity by regulating gene expressions in macrophage-like cell line.

^○Maiko SAKAI, Kohta OHNISHI, Hirokazu OHMINAMI, Masashi MASUDA, Hisami YAMANAKA-OKUMURA, Yutaka TAKETANI (Department of Clinical Food Management, Graduate School of Biomedical Sciences, Tokushima University, Japan)

The 92nd Annual Meeting of JBS

[2P-085] Elucidation of the regulatory mechanism of subcellular localization of the proteasome

^○Ayaka Uera, Shotaro Matsuura, Ayumu Fujiwara, Shoshiro Hirayama, Shigeo Murata (Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo)

The 92nd Annual Meeting of JBS

[2P-086] Elucidation of the regulatory mechanism of subcellular localization of the proteasome by ubiquitin ligase Hul5 during quiescence

^○Noritaka Ohigashi, Shoshiro Hirayama, Hideki Yashiroda, Shigeo Murata (Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo)

The 92nd Annual Meeting of JBS

[2P-087] Nedd8-CUL3 axis is necessary for endothelial cell specificity

^○Tomohisa Sakaue^1,2, Ayako Fujisaki³, Hironori Izutani², Shigeki Higashiyama^1,3 (1.Division of Cell Growth and Tumor Regulation, Proteo-Science Center (PROS), Ehime University, 2.Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, 3.Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine)

The 92nd Annual Meeting of JBS

[2P-088] The N-terminal sequence of murine PRMT5 variant 2 is required for interaction with Hsp70 and CHIP ligase-mediated degradation

^○Weizhe Lu¹, Jun-dal Kim², Saori Tabara³, Chulwon Kwon³, Akiyoshi Fukamizu^1,2 (1.Ph.D. Program in Human Biology, School of Integrative Global Majors (SIGMA), University of Tsukuba, 2.Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 3.Graduate School of Life and Environmental Sciences, University of Tsukuba)

The 92nd Annual Meeting of JBS

[2P-089] A ubiquitin ligase RNF181 plays a pivotal role in the O-GlcNAcylation-mediated cytoprotection under proteasome impairment in cancer cells.

^○Shota Okuno¹, Eiichi Hashimoto¹, Shoshiro Hirayama¹, Hidetaka Kosako², Jun Hamazaki¹, Shigeo Murata¹ (1.Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2.The Division of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Tokushima University)

The 92nd Annual Meeting of JBS

[2P-090] Elucidation of mechanisms regulating the basal proteasome expression

^○Ryo Motosugi, Jun Hamazaki, Shigeo Murata (Laboratory of Protein Metabolism, Graduates school of Pharmaceutical Science, University of Tokyo)

The 92nd Annual Meeting of JBS

[2P-091] Identification of factors modulating the clearance of aggregated tau by genome-wide screening

^○Shinpei Ao, Yasuyuki Sakurai, Shoshiro Hirayama, Shigeo Murata (Laboratory of Protein Metabolism, Graduate Schoo of Pharmaceutical Sciences, The University of Tokyo)

The 92nd Annual Meeting of JBS