15:10 〜 15:20

[1Z05-03(P-209)] Structural and catalytic properties of P219L human D-amino acid oxidase: implications for the ligand binding and catalytic efficiency

^○Wanitcha Rachadech^1,2, Yusuke Kato¹, Rabab M. Abou El-Magd^1,4, Yuji Shishido¹, Soo Hyeon Kim¹, Hirofumi Sogabe¹, Nobuo Maita³, Kazuko Yorita¹, Kiyoshi Fukui¹ (1.Div. of Enzyme Pathophysiol., Inst. for Enzyme Res., Tokushima Univ., 2.Div. of Chemistry, Faculty of Science, Udon Thani Rajabhat Univ., Thailand, 3.Div. of Disease Proteomics, Inst. for Enzyme Res., Tokushima Univ., Japan, 4.Depart. of Psychiatry, Faculty of Medicine, Univ. of Alberta, Canada)

キーテクノロジー：X-ray crystallography

human D-amino acid oxidase、active site lid、point-mutation