The Japanese Biochemical Society

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[2Z09-03(P-633)] An Alzheimer's disease-related mutation in MARK4 promotes tau accumulation and exacerbates neurodegeneration via a gain-of-function mechanism

Toshiya Oba1, Taro Saito1,2, Sawako Simizu1, Akiko Asada1,2, Koichi M. Iijima3,4, Kanae Ando1,2 (1.Tokyo Metropolitan University, Graduate School of Biological Sciences, 2.Tokyo Metropolitan University, Department of Biological Sciences, 3.Department of Alzheimer's Disease Research, National Center for Geriatrics and Gerontology, 4.Department of Experimental Gerontology, Graduate School of Pharmaceutical Sciences, Nagoya City University)

キーテクノロジー:Drosophila model of disease

Par-1/MARK、Alzheimer's disease、tau、phosphorylation、neurodegeneration

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