9:40 AM - 9:50 AM

[3Z04-05(P-364)] MIB2 blocks cell death through ubiquitinating cFLIP

^○Osamu Nakabayashi¹, Hirotaka Takahashi², Shin Murai¹, Fumiaki Ohtake³, Sachiko Komazawa¹, Yuichi Tsuchiya¹, Yasushi Saeki⁴, Yukiko Yoshida⁵, Soh Yamazaki¹, Fuminori Tokunaga⁶, Kenta Moriwaki¹, Tatsuya Sawasaki², Hiroyasu Nakano¹ (1.Department of Biochemistry, Toho University School of Medicine, 2.Division of Cell-Free Sciences, Proteo-Science Center (PROS), Ehime University, 3.Global Research Center for Innovative Life Science, Hoshi University, 4.Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, 5.Ubiquitin Project, Tokyo Metropolitan Institute of Medical Science, 6.Department of Pathobiochemistry, Graduate School of Medicine, Osaka City University)

キーテクノロジー：Genome editing

apoptosis、cFLIP、MIB2、TNF、ubiquitin