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[3Z04-05(P-364)] MIB2 blocks cell death through ubiquitinating cFLIP

Osamu Nakabayashi1, Hirotaka Takahashi2, Shin Murai1, Fumiaki Ohtake3, Sachiko Komazawa1, Yuichi Tsuchiya1, Yasushi Saeki4, Yukiko Yoshida5, Soh Yamazaki1, Fuminori Tokunaga6, Kenta Moriwaki1, Tatsuya Sawasaki2, Hiroyasu Nakano1 (1.Department of Biochemistry, Toho University School of Medicine, 2.Division of Cell-Free Sciences, Proteo-Science Center (PROS), Ehime University, 3.Global Research Center for Innovative Life Science, Hoshi University, 4.Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, 5.Ubiquitin Project, Tokyo Metropolitan Institute of Medical Science, 6.Department of Pathobiochemistry, Graduate School of Medicine, Osaka City University)

キーテクノロジー:Genome editing

apoptosis、cFLIP、MIB2、TNF、ubiquitin

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