[P-359] CDK4/6 inhibitor abemaciclib induces atypical cell death with cytoplasmic vacuoles formation caused by acidification and swelling of lysosome.

^○Hirotsugu Hino^1,2, Noriyoshi Iriyama³, Hiroko Kokuba⁴, Hiromi Kazama¹, Shota Moriya¹, Naoharu Takano¹, Masaki Hiramoto¹, Shin Aizawa², Keisuke Miyazawa¹ (1.Dept. of Biochem, Tokyo Med. Univ., 2.Div. of Anat. Sci., Dept. of Funct. Morpho., Nihon Univ. Sch. of Med., 3.Div. of Hematol. And Rheumatol., Dept. of Med, Nihon Univ. Sch. of Med., 4.Joint Res. Center for Basic Med. Sci., Tokyo Med. Univ.)

キーテクノロジー：ライブセルイメージング

CDK4/6阻害薬、abemaciclib、リソソーム、細胞死、空胞形成