[P-367] Dysfunction of the unfolded protein response transcription factor ATF4 triggers dedifferentiation of pancreatic beta cells

^○Keisuke Kitakaze^1,2, Miho Oyadomari¹, Jun Zhang¹, Kazue Tsugawa¹, Eri Kawano¹, Masato Miyake^1,3, Yasuhiro Takenouchi², Kazuhito Tsuboi², Yasuo Okamoto², Seiichi Oyadomari^1,3 (1.Div. of Mol. Biol., Inst. of Adv. Med. Sci., Tokushima Univ., 2.Dept. of Pharmacol., Kawasaki Med. Sch., 3.Diabetes Therap. and Res. Ctr., Inst. of Adv. Med. Sci., Tokushima Univ.)

キーテクノロジー：コンディショナルノックアウト

小胞体ストレス、UPR、糖尿病、β細胞