[P-774] Generation and characterization of single chain antibodies against occludin preventing hepatitis C virus infection.

^○Yoshimi Shimizu^1,2, Takehiro Shinoda³, Yoshitaka Shirasago¹, Masuo Kondoh⁴, Naoko Shinya³, Kentaro Hanada¹, Kiyohito Yagi⁴, Tetsuro Suzuki⁵, Takaji Wakita⁶, Tomomi Someya³, Mikako Shirouzu³, Masayoshi Fukasawa¹ (1.Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 2.Department of Pharmaceutical Sciences, Teikyo Heisei University, 3.Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, 4.Graduate School of Pharmaceutical Sciences, Osaka University, 5.Department of Infectious Diseases, Hamamatsu University School of Medicine, 6.Department of Virology II, National Institute of Infectious Disease)

キーテクノロジー：抗体改変技術

低分子抗体、Occludin、C型肝炎ウイルス、抗体