[P-545] Analysis of cell death mechanism by MO2455 treatment that induces poly(ADP-ribose) accumulation in mice melanoma B16 cells.

^○Yuka Sasaki^1,2, Takae Onodera^1,2, Kenji Matsuno³, Takeji Takamura⁴, Fumiaki Koizumi^1,5, Mitsuko Masutani^1,2 (1.Dept. Molecular and Genomic Biomedicine, Grad. Sch. Biomed. Sci., Nagasaki Univ., 2.Lab. Collaborative Res., Div. Cell Signaling, Natl. Cancer Ctr. Res. Inst., 3.Faculty of Engineering, Kogakuin university, 4.Faculty of Engineering, Kanagawa inst. of tech., 5.Div. Clin. Res. Support, Komagome Hosp.)

The 93rd Annual Meeting of JBS

[P-546] Gamabufotalin induces cytotoxicity and potentiates cytocidal effect in combination with arsenite in human glioblastoma cells

^○Bo Yuan¹, Kang Xu², Ryota Shimada², Hideki Hayashi², Norio Takagi², Mari Okazaki¹ (1.Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ., 2.Dep. Applied Biochem., Tokyo Univ of Pharm & Life Sci.)

The 93rd Annual Meeting of JBS

[P-547] Induction of apoptosis of hepatocellular carcinoma cells by near-infrared photodynamic treatment with indocyanine green.

^○Yoshinori Inagaki¹, Chikara Shirata¹, Junichi Kaneko¹, Sho Kiritani¹, Masumitsu Sato¹, Takashi Kokudo¹, Nobuhisa Akamatsu¹, Junichi Arita¹, Norihiro Kokudo², Kiyoshi Hasegawa¹ (1.Hepato-biliary-pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, 2.National Center for Global Health and Medicine)

The 93rd Annual Meeting of JBS

[P-548(2Z08-06)] Molecular and genetic backgrounds that modulate the sensitivity of cancer cells to the natural compound AusD

^○Yukiko Kojima¹, Kazuo Shinya², Shingo Dan³, Fuyuki Ishikawa⁴, Mahito Sadaie¹ (1.Tokyo University of Science, 2.National Institute of Advanced Industrial Science and Technology, 3.Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 4.Kyoto University)

The 93rd Annual Meeting of JBS

[P-549] Expression analysis of GREB1 isoform 4 and application to therapy in malignant melanoma

^○Koei Shinzawa¹, Shinji Matsumoto¹, Atsushi Tanemura², Manabu Fujimoto², Akira Kikuchi¹ (1.Departments of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University, 2.Department of Dermatology, Graduate School of Medicine, Osaka University)

The 93rd Annual Meeting of JBS

[P-550] NTSR1 is a potential target for pancreatic cancer

^○Shogo Ehata^1,2, Kei Takahashi¹, Keiji Miyazawa³, Kohei Miyazono¹ (1.Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, 2.Environmental Science Center, The University of Tokyo, 3.Department of Biochemistry, Graduate School of Medicine, University of Yamanashi)

The 93rd Annual Meeting of JBS

[P-551] GREB1, a novel target of Wnt signaling, promotes the development of hepatoblastoma by suppressing TGFβ signaling

^○Shinji Matsumoto¹, Taku Yamamichi², Koei Shinzawa¹, Hiroomi Okuyama², Akira Kikuchi¹ (1.Departments of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University, 2.Departments of Pediatric Surgery,, Graduate School of Medicine, Osaka University)

The 93rd Annual Meeting of JBS

[P-552(2Z08-07)] GREB1 induced by Wnt signaling promotes cell proliferation and tumorigenesis of hepatocellular carcinoma

^○Minami Seta¹, Shinji Matsumoto¹, Takumi Hukumoto², Akira Kikuchi¹ (1.Departments of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University, 2.Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, Kobe University)

The 93rd Annual Meeting of JBS

[P-553] Biological activity of galectin-4 and its roles in colorectal cancer cells growth.

^○Takashi Ogawa¹, Yasuhiro Nonaka¹, Hiroki Shoji², Nozomu Nishi³, Takanori Nakamura¹ (1.Dept. of Endocrin., Faculty of Med., Kagawa Univ., 2.Dept. of Biol., Kanazawa Med. Univ., 3.Life Sci. Res. Center, Kagawa Univ.)

The 93rd Annual Meeting of JBS

[P-554] Production of monoclonal antibodies against three-dimensional culture cancer cells and analysis of the antigens

^○Kenta Soeta, Chikako Yokoyama, Rina Yamaguchi (Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University)

The 93rd Annual Meeting of JBS