[P-415] Roles of FIP200 in the activation of Pyk2 in cultured neuronal cells

^○Sayomi Nakamine, Shiho Okitsu, Reina Miyagi, Hideyuki Yamamoto (Dept. of Biochem., Grad. Sch. of Med., Univ. of Ryukyus, Okinawa, Japan)

The 93rd Annual Meeting of JBS

[P-416] Novel molecular basis of growth factor-regulated cellular glucose metabolism

^○Ryouhei Tsutsumi (Graduate School of Pharmaceutical Sciences, Tohoku University)

The 93rd Annual Meeting of JBS

[P-417] Phospholipase C δ1 Regulates Malignant Phonotypes of Colorectal Cancer Cells via PKCs

^○Mami Odagawa, Sae Ota, Yudai Suzuki, Shiori Kubota, Shinobu Asada, Reiko Satow, Kiyoko Fukami (Tokyo University of Pharmacy and Life Sciences, Laboratory of Genome and Biosignals)

The 93rd Annual Meeting of JBS

[P-418(1Z10-07)] Electron microscopic observation of multimer induced by chemical modification of HVR domain in the small G-protein Ras

^○Rufiat Nahar¹, Shinsaku Maruta¹, Makoto Fiyata², Yuhei Tahara² (1.Soka University, 2.Osaka city university)

The 93rd Annual Meeting of JBS

[P-419] A four-state transition model for the intracellular localization of Rab7 in endolysosomal pathway

^○Akane Kanamitsu, Shingo Koinuma, Takeshi Nakamura (Division of Biosignaling, Research Institute for Biomedical Sciences, Tokyo University of Science)

The 93rd Annual Meeting of JBS

[P-420(1Z10-08)] Molecular mechanism of GPCR-kinase selectivity at μ-opioid receptor

Suzune Hiratsuka¹, Kouki Kawakami¹, ^○Misaki Yoshida¹, Junken Aoki^2,3, Asuka Inoue^1,3 (1.Dept. of Mol. Cell. Biochem., Grad. Sch. of Pharm. Sci., Tohoku Univ., 2.Dept. of Health Chem., Grad. Sch. of Pharm. Sci. Univ. of Tokyo, 3.LEAP, AMED)

The 93rd Annual Meeting of JBS

[P-421(1Z10-09)] Analysis of G12 signaling in vivo by using G12-coupled Designer GPCR.

^○Yuki Ono¹, Asuka Inoue^1,2 (1.Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan, 2.LEAP, AMED)

The 93rd Annual Meeting of JBS

[P-422] Molecular Mechanisms of G-protein dependent β-arrestin biased agonism in Angiotensin2(AT1) receptor.

^○Kouki Kawakami¹, Masataka Yanagawa², Suzune hiratsuka¹, Arun K. Shukla³, Yasushi Sako², Junken Aoki^1,4,5, Asuka Inoue^1,5,6 (1.Dept. of Mol. Cell. Biochem., Grad. Sch. of Pharm. Sci., Tohoku Univ., 2.Cellular Informatics Laboratory, RIKEN Cluster for Pioneering Research, 3.Indian Institute of Technology, Kanpur, 4.Dept. of Health Chem., Grad. Sch. of Pharm. Sci., Univ. of Tokyo, 5.LEAP, AMED, 6.PRIME, AMED)

The 93rd Annual Meeting of JBS

[P-423(1Z10-10)] The regulation of PLEKHG1, a Rho guanine nucleotide exchange factor, by non-receptor tyrosine kinase FYN

^○Shun Nakano¹, Masashi Nishikawa², Tomoyo Kobayashi³, Tuyoshi Sugiyama⁴, Hisashi Yamakawa⁵, Takahiro Nagase⁵, Hiroshi Ueda^1,3 (1.United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 2.Aichi Developmental Disability Center, 3.Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 4.Department of Pharmacy, Faculty of Pharmacy, Gifu University of Medical Science, 5.Kazusa DNA Research Institute)

The 93rd Annual Meeting of JBS

[P-424] Real-time Monitoring of Gαq-PLCβinteraction using Nanoluc complementation system (NanoBiT) and its application to Gq-coupled GPCRs

^○Yuki Saigo¹, Kouki Kawakami¹, Suzune Hiratsuka¹, Junken Aoki^2,3, Asuka Inoue^1,3,4 (1.Dept. of Mol. Cell. Biochem., Grad. Sch. of Pharm. Sci., Tohoku Univ., 2.Dept. of Health Chem., Grad. Sch. of Pharm. Sci., Univ. of Tokyo, 3.LEAP, AMED, 4.PRIME, AMED)

The 93rd Annual Meeting of JBS